肝臓
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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C型慢性肝炎に対するpegylated interferon α-2b/ribavirin併用療法の無効・再燃例におけるpegylated interferon α-2a/ribavirin併用療法の効果
平井 聡荻野 英朗梶 喜一郎舩木 雅也島谷 明義堀田 洋介松田 耕一郎平松 活志松田 充野田 八嗣
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2011 年 52 巻 4 号 p. 251-254

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We investigated the efficacy of peginterferon alfa-2a plus ribavirin (α-2a therapy) for chronic hepatitis C patients who relapsed or did not respond to peginterferon alfa-2b plus ribavirin (α-2b therapy). Eleven patients with relapse and 5 non-responders to α-2b therapy received α-2a therapy for 48 to 72 weeks. In those with relapse, the rate of RVR, complete EVR and SVR were 54.5%, 72.7% and 72.7%, respectively. In non-responders, the rate of RVR, complete EVR and SVR were all 0%. Three of 5 LVR patients on α-2b therapy achieved SVR on α-2a therapy. Our findings suggest that patients showing relapse on α-2b therapy could achieve an early viral response and high SVR rate on α-2a therapy, non-responders could not.

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© 2011 一般社団法人 日本肝臓学会
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