Direct-acting antivirals（DAA）によるC型肝炎ウイルス排除後早期の肝発癌例の画像所見の検討

抄録

Direct-acting antivirals (DAA) are an effective treatment for hepatitis C virus infection. Hepatocellular carcinoma (HCC), however, has also been reported to occur after sustained virologic response (SVR) and the clinical features remain unknown. We investigated the characteristics on imaging of HCC that developed after achieving SVR with DAAs. As results, all 12 patients (DAA-SVR HCC) showed high intensity on diffusion-weighted magnetic resonance imaging (DWI) and the DWI positivity was significantly higher than that in HCC patients without viral eradication (HCV-RNA positive HCC). Moreover, all DAA-SVR HCC cases showed hypoechoic results in the Kupffer phase of contrast-enhanced ultrasonography with Sonazoid. Our results suggested that the biological nature of DAA-SVR HCC would be different from that of HCV-RNA positive HCC.