1980 Volume 21 Issue 11 Pages 1513-1519
Seven patients with infectious mononucleosis admitted to National Shimonoseki Hospital during recent one year are reported. All cases had characteristic signs and symptoms of infectious mononucleosis as described by Evans, and were complicated by severe hepatitis. The diagnosis was comfirmed by the tests for various antibodies against Epstein-Barr virus. Five of seven patients had significantly high titer of IgM and or IgG antibodies to viral capsid antigen.
Patients with EBV antibody positive infectious mononucleosis tended to have a high levels of serum IgM and patients with EBV antibody negative infectious mononucleosis tended to show high level of serum transaminase.
In infectious mononucleosis hepatitis of all 4 cases studied, focal necrosis was observed as Well as portal and intralobular infiltlates of inflammatory cells, predominantly lymphocytes. The present study indicates that infectious mononucleosis is not so rare in Japan and sometimes complicates with severe hepatitis.