Abstract
It was reported that horse anti-AFP serum had a suppressive effect on 3'-Me-DAB rat hepatoma.
In order to clarify the mechanism of the effect, the correlation between tissue AFP and administered anti-AFP was immunohistochemically investigated.
The result was characterized by a decrease in the number of AFP positive cells, and the proven localization of horse immunoglobulin in the liver of rats treated with anti-AFP specific antibody.
This fact indicates the possibility of AFP-anti AFP immunoreaction at the site of AFP producing cells, and it is suggested that this Ag-Ab reaction may cause the suppressive effect on 3'-Me-DAB rat hepatoma.
