Abstract
One hundred and sixty-one patients with hepatocellular carcinoma was studied. Fifteen (9.3%) out of them had no liver cirrhosis. Incidense of patients with Hepatitis B surface antigen in the serum was slightly higher in noncirrhotic cases (6/15, 40.0%) than cirrhotic (31/146, 21.2%), but no significant difference was found in age, sex, history of blood transfusion, and amount of alcohol intake.
Histology of noncancerous part of liver in HBs antigen positive cases were liver fibrosis in 4 and chronic persistent hepatitis in 2. While in HBs antigen negative cases, chronic aggresive hepatitis 2A in 4, chronic aggressive hepatitis 2B in 2, liver fibrosis in 2, and normal liver in 1. Thus activity of liver disease was quite different between those with and without HBs antigen in the serum.
Five patients under medical follow up were successfully treated by hepatectomy in 3, and by transcatheter arterial embolization in 2. In other ten patients without medical service, only one was treated with surgery and two with embolization therapy. If cases with HBs antigen positive liver disease and cases with HBs antigen negative chronic hepatitis will be followed up medically, we can perform more useful treatment for patients with hepatocellular carcinoma without liver cirrhosis.
