Abstract
The effects of ethanol on hepatocytic regeneration were studied in rats. With acute administration of ethanol, DNA synthesis and commencement of the S phase of the cell cycle in hepatocytes after partial hepatectomy were delayed. For chronic ethanol administration, DNA synthesis after partial hepatectomy was clearly reduced and commencement of the S phase was retarded. These results indicate that both acute and chronic administrations of ethanol inhibit hepatocytic regeneration.
