Abstract
Tritiated platelet activating factor (3H-PAF) was injected into the tail vein of rats and the radioactivities in blood, lung, spleen, liver and brain were determined at valious time intervals by a liquid scintillation counter. The radioactivity in 0.1g of various tissues reached at their maximus 5min after 3H-PAF injection and declined thereafter. These declines were especially remarkable in blood, spleen and lung, while the radioactivity was remained for considerably longer time in liver and kidney. When total radioactivity incorporated into and remained in various organs were calculated, it was shown that the liver was the most injection of 3H-PAF. On the other hand, incorporation into the brain was very low and no change in radioactivity was detected during the observation. These results suggested that the liver might be an important organ in metabolism of PAF and PAF might play some role in inflammatory reaction in liver.
