Abstract
This study was aimed to evaluate the hepatic hemodynamics after portal vein ligation (PVL). Terminal portal venous (TPV) and central venous (CV) pressures measured by a micropuncture method and the relationships among the prssures, the hepatic blood flow (HBF) and the formation of collateral veins to the liver were studied in the rat model with porta-systemic shunt. Although the TPV pressure, the TPV-CV pressure differences, and the HBF were decreased immediately after PVL, the TPV pressure and the TPV-CV pressure differences were normalized after 4 weeks of PVL and the HBF was returned to the prevalues 3 days after PVL. Portogram showed that collateral veins to the liver were found to be created after 1 week of PVL, and that they were remarkably developed after 4 weeks with clearly shown intrahepatic portal veins. Because the improvement of the TPV pressure and the TPV-CV pressure differences were well correlated with the formation of collateral veins to the liver, the results suggest that the hepatic arterial blood flow was compensationally increased after 3 days of PVL and that the portal venous blood flow was recovered accompanying with the formation of the collateral veins to the liver.
