Abstract
We report an autopsy case of neoplatic angioendotheliosis (NAE) with extravascular tumor formation in the liver. A 77-year-old woman, who had been followed with chronic hepatitis of ten years' duration was admitted to our hospital for a treatment of ascites and unknown fever. She was pointed out liver cirrhosis by ultrasonogram and biochemical examination on admition. Ascites and unknown fever did not improve by diuretics and antibiotics. Hypoechoic tumor, approximately 2cm in diameter, was detected in S5 area of the liver by ultrasonogram, and hepatocellular carcinoma was most suspected. She died of hepatic and renal failures one month after admission, and autopsy was performed.
Grossly, whitish solid mass with well-demarcated margins, measuring 2.0×1.7cm in size was located in S5 area of the liver. Histologically, the tumor consisted of a solid proliferation of large blastoid cells with a little fibrillay elements. Numerous tumor cells were also found in the lumen of the small vessels in various organs including the liver. The tumor cells were found to be positive for both leukocyte common antigen and pan B cell antigen. The liver tumor was diagnosed as extravascular tumor formatian of NAE.
