Abstract
The present study was performed in order to investigate histopathologically the healing process of the bone defects to sintered bone (bovine bone) which was implanted into artificially created bone defects in domestic rabbits. The results were as follows : 1. At two weeks after implantation in bone defects, there was slight inflammatory cell infiltration. Sintered bone was embedded in the new bone. 2. At four weeks, some of sintered bone was directly connected with new bone tissues. Neither foregin body reaction nor inflammatory cell infiltration was observed. 3. Considering above results, it was suggested that sintered bone was non-inflammatory and non-stimulative. Further sintered bone had good tissue tolerance and osteogenic activity. In these investigations, sintered bone is considered to be useful as bone graft material for oral surgery.
