Kekkaku(Tuberculosis)
Online ISSN : 1884-2410
Print ISSN : 0022-9776
INTERACTION OF RIFAMPICIN AND HYDROCORTISONE-SUCCINATE
Takeshi KITAOKunio RONDOShinji NAKAOHidesaku ASAKURAYuichi ARAI
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1986 Volume 61 Issue 2 Pages 71-74

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Abstract

The pharmacokinetics of hydrocortisone succinate were studied in four patients who were on rifampicin (group hydrocortisone+RFP). The maximum plasma concentration of cortisol (hydrocortisone) in group (hydrocortisone+RFP) was as low as 40% of that in control patients (group hydrocortisone). The difference in area under curve (AUC) and plasma half life between group (hydrocortisone + RFP) and group (hydrocortisone) was statistically non-significant.

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© THE JAPANESE SOCIETY FOR TUBERCULOSIS
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