2008 Volume 43 Issue 3 Pages 225-228
In order to analyze the defensive mechanisms against high concentrations of CuSO4 in the copper-tolerant yeast, Cryptococcus liquefaciens (N6 strain), morphology analysis and analytical electron microscopy were conducted on. Copper was detected in strain N6. Copper was distributed in the cytoplasm, rather than in small vacuoles. These results suggest that cytoplasmic and/or some other proteins with a high affinity to heavy metals, may have a role in the defensive mechanisms against high concentrations of CuSO4, as a chelator, in the N6 strain.