In order to restore damaged joint functions, the prosthesis has been widely implanted into the joint part in recent years. However, the biononconformance often occurs after the reimplantation. In this paper, the shape optimization of a hip prosthesis stem in the total hip replacement was investigated using growth-strain method. At first, growth criterion parameters of femur were sought by applying finite element method for the mechanical adaptive growth behavior of femur. By this analysis, the effect of stress shielding on femur inserted with the prosthesis stem was investigated. Then, the optimum shape of the prosthesis stem was created by growing the stem not so as to be occurred the bone resorption on femur. It was found that the stem shape had effects on the bone resorption of femur.