マイクロ流体デバイス内で起こる反応の収率予測法と並列接続デバイスによる増産の実証

抄録

The yields of consecutive reactions in a micro-fluid device were predicted by using Monte Carlo simulation. It was found that the yield of main product was improved by using a micro-fluid device when the ratio of the reaction rate constants is k₁/k₂ >1. The yield prediction map was also made by using non-dimensional Damkohler Number Da and the ratio of the reaction-rate constants k₁/k₂. The validation experiments of four kinds of consecutive reactions were conducted. Next, the micro-fluid system of 20 parallel-connected micro-fluid devices was developed. The maximum flow rate of the micro-fluid system was 10 mm³/s, which corresponds to 315 t/year. Evaluation of the chemical performance of the micro-fluid system was conducted using a nitration reaction. It was found that the micro-fluid system increased the production scale without decreasing the yield of the products.