This study deals with the development of a method for ball screw generation. The method is based on a generation process that uses a standard-shaped grinding wheel, instead of a form-grinding process that uses a form-dressed grinding wheel, and requires no extensive form-dressing process. In the previous study, the wheel axis is set three-dimensionally at the computed optimum angle of inclination consist of the tilt and swivel angle. However, it needs a complex working process, because the shape generated by the method is asymmetric. In this study, in order to acquire a symmetrically generated shape, the wheel axis is set two-dimensionally at the computed optimum tilt angle, and the swivel angle is set as 0. The optimum tile angle that gives a minimum geometrical error is determined by a numerical simulation of the generation process with the aid of a computer. The results of grinding experiments show that the present method reduces processing steps and working time. Through the grinding simulation and generation experiments, it is shown that the ball screw generation method with two-dimensional setting of the wheel axis has great advantages in manufacturing.