This study discusses the positioning and vibration control of time-varying vibration systems whose parameters are time-varying. We assume that the time-varying parameter of a vibration system is detected by an on-line measurement or Wavelet analysis. This paper treats two control methods using nonstationary optimal regulators (NOR) for this problem. The first method is a gainscheduling of NORs. An actual controller is obtained by the interpolation of plural NORs designed a priori. The other one is an NOR design based on Wavelet analysis of the vibration system. In the second case, single NOR derived from the analysis result is applied. This study shows the effectiveness of these methods by numerical calculations and experiments. From the comparison of these methods, this paper suggests suitable applications of NOR according to the characteristics of each control problem.