2016 年 66 巻 2 号 p. 111-116
Background & Aims: The correlation between low serum dehydroepiandrosterone sulfate (DHEA-S) levels and coronary artery disease (CAD) is yet unclear. Therefore, we investigated the correlation between DHEA-S levels and the presence or severity of CAD in middle-aged and elderly men.
Methods: Fifty-six consecutive middle-aged and elderly men who underwent selective coronary angiography were divided into the CAD group (n= 41) and control group (without CAD; n= 15). CAD was defined as≥75% occlusion in≥1 major coronary arteries. Serum DHEA-S, lipid, and plasma glucose levels were determined after a 12-h fast. Coronary artery stenosis severity was estimated using the Gensini score.
Results: DHEA-S levels were significantly lower in the CAD group than in the control group; however, other clinical parameters showed no difference between the groups. An age-adjusted multiple regression analysis revealed that DHEA-S-dependent determinants were significantly correlated with the Gensini score (β=-0.291, p<0.05), but not with other clinical parameters.
Conclusions: Middle-aged and elderly men with CAD may have lower serum DHEA-S levels than age-matched men without CAD, and serum DHEA-S levels may negatively correlate with coronary artery stenosis severity in all men, suggesting a cardioprotective effect of DHEA-S.
