Methotrexate-associated Lymphoproliferative Disorders:

Drug Withdrawal Caused Pharyngeal Lesion Healing

Abstract

Oral administration of Methotrexate (MTX) for rheumatoid arthritis caused Methotrexate-associated lymphoproliferative disorders (MTX-LPD), although just only drug withdrawal has a possibility to cure MTX-LPD rapidly.　The purpose of consulting to the ear-nose-throat doctor (ENT doctor) is a biopsy from the lesion, and getting pathological diagnosis, whereas some patients stopped taking MTX drugs before visiting to the ENT doctor. As a result, MTX-LPD lesion disappeared rapidly, and it could not be diagnosed any more. During a follow-up examination in that case, some MTX-LPD suspected lesions developed to the malignant lymphoma. Biopsy before withdrawal of MTX is important.　Moreover, carefully watching of lesions, and frequently examination of patients are really needed to MTX-LPD.