Abstract
In experimental Salmonellosis, produced in mice with S. enteritidis, Mice, immunized with 10-5mg of an attenuated strain of S. enteritidis (SER), and 3 weeks threeafter reimmunized with 10-7mg of a virulent strain of this bacillus, achieved high grade immunity and survived the challenge of 1, 000MLD of the virulent strain.
On the other hand immunized mice acquired hypersensitivity against the endotoxin of S.enterisidis and showed marked hyaline granules in the liver cells accompanied by severe damage.
In the previous papers, we reported the experimental condition of the appearance of hyaline granules and histochemical characters.
In this report, we performed the nonspecific immunization or repeated immunization with endotoxin and both results in hypersensitivity against the endotoxin and appearance of hyaline granules.
Mice immunized with living vaccine of S. enteritidis showed anaphylactic shock against the endotoxin of E. coli which had no common antigens with S. enteritidis and died with in 24 hours accompanied by marked hyaline granules.
In the other group, imumnization was done by repeated subcutaneous and intraperitoneal injection of the endotoxin of S. enteritidis amounting to 0.15mg in total with in 25 days. Anaphylactic shock was induced by the same endotoxin injection given after the interval of 10 days and appearance of hyaine granules was conspicuous.
It is considered that hypersensitivity against the endotoxin nonspecific with regard to the O-antigen and immunization with the living vaccine of S. enteritidis induced antilethal resistance against the infection with the virulent strain of living vaccine but repeated immunization with endotoxins in the subcutis and the peritoneal cavity, produced hypersensitivity against the same endotoxin accompanied by marked hyaline granules.
It seemed interesting to us that interrelation was found between the hypersensitivity and appearance of hyaline granules.
