ON THE ROD-SHAPED VIRUS-LIKE PARTICLES APPEARED IN THE BUDR-TREATED HUMAN EMBRYO CELL CULTURE

Abstract

It has been demonstrated electron microscopically that rod-shaped virus-like particles were found in the human embryo cell culture when the cells were treated with 5-bromodeoxyuridine (BuDR) in culture. The rod-shaped particles, measuring approximately 70 nm in width and 300 to 400 nm in length, are composed of doubled, outer and inner, tubular structures whose both ends are closed. They appeared in clusters in the multiply formed intracytoplasmic vesicles of the treated cells. It was noticed that they resembled the tublar particles appeared in the BuDR-treated mouse sarcoma cells. The nature of the tubular particles is not known at present.