慢性胃炎に関する臨床的研究

(第1報) -2, 3の薬物の臨床効果と血中ガストリン動態

抄録

The pathophysiology of chronic gastritis remains to be determined. Metoclopramide, sulpiride and γ-Oryzanol, drugs which mainly act on the central nervous system, were reported to be effective against various complaints in patients with chronic gastritis. The aim of the present study was to analyze the part of pathophysiology of chronic gastritis. In addition, the effects of these drugs on clinical evaluations were compared.
Nineteen patients with chronic gastritis (aged 25 to 74 years), 21 men and 8 women, were studied. All patients were orally given a therapeutic dose of metoclopramide (30 mg/day), sulpiride (300 mg/ day) and γ-oryzanol (300 mg/day) for 4 weeks. Serum gastrin was determined by radioimmunoassay. The results obtained herein were as follows :
1. Sixty two % of the patients was found to be neurotic, suggested by the method of modification of CMI test.
2. Various kinds of complaints were observed in patients with chronic gastritis. These include nausea, fatigability, and postpradial fullness and discomfort in the upper abdomen.
3. The effective rates of metoclopramide, sulpiride and γ-oryzanol against various complaints were 66.7%, 86.7% and 75.0%, respectively. It was of interest to note that sulpiride was the most effective against psychic complaints.
4. Administration of γ-oryzanol resulted in decreased serum gastrin levels, while no change was observed in metoclopramide or sulpiride-treated groups.
5. No effect by these drugs on the rate of secretion of gastric juice was found.