N ACETYL β GLUCOSAMINIDASE, α1 MICROGLOBULIN, AND β2 MICROGLOBULIN AS INDICATORS OF RENAL FUNCTION AFTHR OPEN-HEART SURGERY

Abstract

Renal function after open-heart surgery was studied using urinary N acetyl β glucosaminidase (NAG), α1 microglobulin (α1M), and β2 microglobulin (β2M). These parameters were compared with creatinine clearance (Ccr), fractional excretion of sodium (FeNa), and free water clearance (FWC), from the preoperative period through the to seventh post-operative day. Although postoperative courses were uneventful and values of Ccr, FeNa, and FWC were improved or unchanged, NAG, α1M, and β2M levels were significantly elevated (P <0.05) until the 7 th, 6 th and 2 nd postoperative day, respectively. The above data indicate that subclinical renal failure exists several days after open-heart surgery. The values of Ccr, FeNa, and FWC did not correlate with NAG, α1M, and β2M. NAG, α1M, and β2M levels are of minimal diagnostic significance for acute renal failure.