After the administration of Rb86Cl to male mice of dd strain weighing about 20 g, its absorption, distribution, excretion. and effects of alkali salts and diuretics upon these were investigated with the following results :
1) The rate of absorption of Rb from the alimentary canal was 50 and 67 % in 30 and 60 minutes, respectively. In the beginning, much of the adsorbed Rb86 collected in the kidney.
2) The excretion of subcutaneously given Rb86 was highest on the first day 8.5 and 2.5% into urine and feces, respectively, and thereafter gradually declined. The total excretion in a week amounted to 48%. The excretion into urine was about 3.2 times that into feces. 3) The distribution of Rb86 at the 1st, 4th and 7th days of the administration was in the order of pancreas > liver > muscle ≥ testis > kidney > bone > blood. 4) The administration of isotonic KCl and NaCl solution tended to accelerate the excretion of Rb86, exhibiting decrease in its concentration in the body. 5) The administration of RbCl in a small dose, separately or by added to Rb86, accelerated the excretion of Rb86, but in a larger dose, it conversely showed tendency of inhibition. 6) The administration of Diamox in 0.10.5 mg either gave no change in the excretion, or rather tended to inhibit it. 7) The administration of NH4Cl accelerated the excretion, decreasing its concentration in the body. 8) The administration of mercuric diuretic produced no change in the excretion and in its distribution in the body.