Abstract
It has already been evidenced that saliva parotin has accelerating action on dentine calcification. Now, this saliva parotin was separated into heavy and light fraction by ultracentrifugation, and effect of each fraction on dentine calcification and development was investigated by our method (1) (2). The following facts were evidenced from these experiments.
(1) Action of the heavy fraction on calcification and development of dentine was more than 100 times stronger, and that of the light fraction was milder than the original saliva parotin.
(2) And this action of the heavy fraction could not be distinguished from that of parotin or saliva parotin in its quality. Namely, administration of its smaller dose accelerated, and that of its larger dose inhibited development, formation and calcification of dentine.
(3) Change in serum calcium seemed to be secondary phenomenon. Slight alkalosis was considered to be rather significant.
