KONA Powder and Particle Journal
Online ISSN : 2187-5537
Print ISSN : 0288-4534
ISSN-L : 0288-4534
Original Research Papers
Continuous Synthesis of Precision Gold Nanoparticles Using a Flow Reactor
Jiaqi DongJonathan LauSpyros A. SvoronosBrij M. Moudgil
Author information
J-STAGE Data Supplementary material

2022 Volume 39 Pages 262-269


Nanoparticle synthesis using flow chemistry has the potential to enhance the large-scale accessibility of precision-engineered nanomaterials at lower prices. This goal has been difficult to achieve primarily due to reactor fouling and the lack of efficient reagent mixing encountered, especially in those scaled-up systems. The present study aimed to overcome the two challenges by integrating a liquid-liquid biphasic segmented flow system with static mixing. This strategy was applied to the synthesis of gold nanoparticles (AuNPs) using citrate reduction chemistry. It was demonstrated that reactor fouling was eliminated by implementing the biphasic flow strategy. As a result, the overall mean particle size of the as-synthesized AuNPs was measured to be 15.5 nm with a polydispersity index (PDI) of 0.07, and with the reproducibility of ± 6.4 %. The biphasic flow system achieved a reaction yield of 88.7 ± 1.1 % reliably with a throughput of 60 mL/hour up to 8 hours.

Fullsize Image
Content from these authors

This article is licensed under a Creative Commons [Attribution 4.0 International] license.
Previous article Next article