口腔領域における惡性腫瘍の臨床的経過に伴う血漿蛋白分屑の変動並びに赤沈値の消長に関する研究第1報

抄録

Since the protein fraction in body-fluid was analyzed exactly by Tiselius method in electrophoresis, the analysis of the serum or plasma protein in pathologic conditions have been reported by many investigators.
On the other hand, many researches on correlations between erythrocyte sedimentation rate and the fractions of plasma proteins has been done. Among them, the most interesting point is that the correlation of the fractions is varied by the kind of the disease. The same tendency is observed in the accelerating and delaying factors for the erythrocyte sedimentation.
The analysis of fractions and the measurements of erythrocyte sedimentation of 25 oral cancer patients were performed in order to determine the correlation between each fraction and erythrocyte sedimentation. These analysis and measurements were repeated 114 times.
At first, the fluctuation of fractions in plasma proteins were observed and obtained the following results.
1) In the patients of oral cancer before treatment, decreasing of albumin and the increasing of α-globulin and fibrinogen in plasma protein were observed.
2) The plasma protein pattern kept abreast with the changes in clinical findings. The more did the clinical findings change, the more they increased remarkably, and especially there was a significance between the decrease of albumin and the increase of globulin.
3) After the treatment, the plasma protein pattern showed the variation by artificial stress like an operation. However, they were stabilized within 60 th or 70 th day after the treatment. In the cases showing the favorable prognosis, the plasma protein would gradually returned to the normal level, while, in the cases showing unfavorable prognosis, it would become unstabilized again, that is, the decreasing of albumin and the increasing of α- and γ-globulin and fibrinogen could be seen. Only β-globulin did not show so prominent variation through all phases of the disease.