The Kurume Medical Journal
Online ISSN : 1881-2090
Print ISSN : 0023-5679
STUDIES ON THE VISUAL EVOKED RESPONSES TO PAIRED LIGHT FLASHES IN SCHIZOPHRENICS
KIICHI ISHIKAWA
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1968 Volume 15 Issue 3 Pages 153-167

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Abstract

This study was conducted to compare the VER characteristics of schizophrenics (41 pre-drung and 47 on-drug patients) with those of 38 normal controls by using a recovery function technique, and to detect possible correlations between the recovery curve and some clinical symptoms of schizophrenics. The results were as follows: 1) There were no significant differences between the amplitude and age or sex, and between the amplitude and clinical types or presumptive onsets of schizophrenics. 2) The mean amplitudes of R1 and R2 were consistently lower in the predrug group and higher in the on-drug group than in the normal group. As to the distribution of the greatest amplitude, the pre-drug group also showed significantly higher percentage of cases with lower amplitude below 10 μV as compared to the remaining groups. 3) The mean recovery curves indicated a nearly identical pattern in all groups. But somewhat meaningful difference between controls and schizophrenics was found at 140 and 160 msec intervals. The latter presented higher value than the former. 4) In regard to the distribution of the greatest value of R2 : R1 ratio in each subject, the higher ratios above 2.0 were found in the schizophrenics more than in the controls. But the on-drug group showed significantly higher percentage of cases with the ratios above 4.0 in comparison to the pre-drug group. 5) The most important results in this study were the findings that 80 percent of the patients with the maximal supernormal peak at the 140 msec interval, had manifested hallucination, and on the contrary, 50 percent of the patients with hallucination showed the maximal supernormal peak at the 140 msec interval, whereas the majority of non-hallucinatory groups presented the peak at the interval of 100 msec. These findings were highly suggestive of the correlation between the increased responsiveness of the R2 at the 140 msec interval and the presence of hallucination. And relationship of these findings with the facilitation of the fundamental driving responses of EEG to 7 c/s flickering light was briefly discussed.

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