2016 Volume 28 Issue 1 Pages 5-9
Chemoradiotherapy has become the most popular in modality of laryngeal preservation treatment for patients with locally advanced laryngeal cancer. However, larynx-preservation surgery is only an option in select patients with T3-4a laryngeal cancer, and it may be able to achieve organ-preservation without chemoradiotherapy. In this study, we reviewed the medical records of 13 patients with locally advanced laryngeal squamous cell carcinoma who were primarily treated with organ-preservation surgery. We defined organ-preservation as （1）local relapse-free, （2） survival,（3） eating a regular diet, （4） no requirement for a feeding tube and （5） decannulation in this report. The 3-year overall survival rates were 100% for cT3, 75% for cT4a and 92% for all. None of the patients experienced any local recurrences, and the 3-year locoregional control rates were 78% for T3, 100% for T4 and 84% for all. The 3-year organ-preservation rates were 89% for T3, 50% for T4 and 76% for all. The 3 -year radiotherapy-avoidance rates were 56% for T 3 , 0% for T 4 and 38% for all. Larynxpreservation surgery can produce a substantial local control and organ-preservation rate in locally advanced laryngeal cancers. Additionally, in select T3 laryngeal cancers, it can achieve both organ-preservation and radiotherapy-avoidance.
