Spindle Cell Carcinoma of the Larynx ; A Clinicopathologic Study of Three Cases

Abstract

Three cases with laryngeal spindle cell carcinoma, a relatively rare malignancy, were reported on in this study. Every case had hoarseness as a chief compliant and was treated by radiation and surgery.
Case 1 (67-years-old male) and case 2 (63-years-old male) had polypoid mass appear in their larynx and underwent biopsy by laryngo-microscopic tumor resection. The histopathological diagnosis in both cases was spindle cell carcinoma. Postoperative radiotherapy was performed. Case 1 had complete response (CR) but case 2 had progressive disease (PD). The latter had a subsequent total laryngectomy; however, the postoperative histopathological findings revealed only fibrosis with no malignant cells.
Case 3 (62-years-old male) was treated with radiotherapy for early stage squamous cell carcinoma of the larynx. The malady was diagnosed with a small specimen removed by fiberscopy. Case 3 had CR, but two years after radiation therapy, relapse of the tumor was found via laryngomicroscopic biopsy. The resulting histopathological diagnosis was spindle cell carcinoma and case 3 had a following partial laryngectomy.
Histopathological findings for spindle cell carcinoma are quite varied, therefore a biopsy with a larger specimen is recommended in order to grasp the whole image and obtain a more definite diagnosis.