FABMS を用いたオリゴ糖類のキラル認識能評価

抄録

Chiral recognition ability of permethylated oligosaccharides toward amino acid derivatives was evaluated by the FAB mass spectrometry/enantiomer labelled guest method. Among the permethylated oligosaccharides, fructofuranose (MeFruNys) showed remarkable chiral recognition ability. It was clarified that MeFruNys adopts “induced-fitting chiral recognition” as the chiral recognition mechanism. Moreover, new linear chiral hosts were designed on the basis of the structural features of MeFruNys, and then, synthesized. Their host also showed chiral recognition. One of the hosts was utilized as a reagent for evaluation of optical purity of the chiral guests.