一般論文
Mass Spectrometric Elucidation of Phenolic Oxidation Processes with Cu2+-Adduct
2007 年 55 巻 1 号 p. 7-13
詳細
2007 年 55 巻 1 号 p. 7-13
Formation of ε complex with 2-hydroxy-6-[8′(Z),11′(Z),14′-pentadecatrienyl]benzoic acid (anacardic acid) and copper ion in the respective ratios of 2 : 1 and 1 : 1 at room temperature was observed by electrospray ionization mass spectrometry. The oxidation of 3-(3,4-dihydroxyphenyl)alanine (DOPA) in the presence of anacardic acid showed competitive inhibition with temporary reduction from dopaquinone to DOPA. In the oxidation of neurotensin, the oxidized products, dopaquinone-derivatives, were observed. Mass spectrometry revealed that the enzymatic oxidation of tyrosine residue is inhibited by anacardic acid.
