Mass Spectrometry
Online ISSN : 2186-5116
Print ISSN : 2187-137X
ISSN-L : 2186-5116
Imaging Isomers on a Biological Surface: A Review
Britt S. R. ClaesEmi TakeoEiichiro FukusakiShuichi ShimmaRon M. A. Heeren
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2019 Volume 8 Issue 1 Pages A0078


Mass spectrometry imaging is an imaging technology that allows the localization and identification of molecules on (biological) sample surfaces. Obtaining the localization of a compound in tissue is of great value in biological research. Yet, the identification of compounds remains a challenge. Mass spectrometry alone, even with high-mass resolution, cannot always distinguish between the subtle structural differences of isomeric compounds. This review discusses recent advances in mass spectrometry imaging of lipids, steroid hormones, amino acids and proteins that allow imaging with isomeric resolution. These improvements in detailed identification can give new insights into the local biological activity of isomers.

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© 2019 Britt S. R. Claes, Emi Takeo, Eiichiro Fukusaki, Shuichi Shimma, and Ron M. A. Heeren. This is an open access article distributed under the terms of Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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