MATERIALS TRANSACTIONS
Online ISSN : 1347-5320
Print ISSN : 1345-9678
ISSN-L : 1345-9678
Biodegradation of Pure Magnesium and Bone Tissue Reaction in Rabbit Femur 1 Year Results of 3D Micro-CT Monitoring and Histological Observation
Akane IshikawaJun TamuraToshikazu AkahoriTomokazu HattoriMasataka Deie
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2017 Volume 58 Issue 1 Pages 118-122

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Abstract

Pure magnesium and its alloys are biocompatible and biodegradable. In cardiovascular surgery, they have been experimentally applied for short-term use as tiny devices. Many studies have been performed on rats and mice using X-ray imaging and CT scanning. However, these small animals have a low radiation resistance and the lethal exposure dosage is small. In orthopedic surgery, fracture fixation using magnesium materials has high potential applicability. Although long-term stable fixation is required, few long-term animal studies have been performed. Therefore, many unclear issues still remain. Accordingly a long-term animal study was performed on Dutch rabbits to investigate the biodegradation of pure magnesium. Specimens implanted into rabbit femurs showed a volume reduction of 40–50% at 52 weeks. Bone resorption was observed in cancellous bone, and new bone formation and direct contact were partially observed. No magnesium hydroxide was observed in the surrounding area.

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© 2016 The Japan Institute of Metals and Materials
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