Online ISSN : 1347-5320
Print ISSN : 1345-9678
ISSN-L : 1345-9678
Fabrication of the Silicate Containing CaTiO3 Film with Hydrophilic and Smooth Surface on Titanium to Improve Osteoconductivity
Liwei ZhuYou SaitoKoji KoikeKensuke KurodaMasazumi Okido
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2019 年 60 巻 9 号 p. 1807-1813


It has been reported that hydrophilicity and hydrophobicity of implants influenced the bioactivity. However, it is hard to maintain the hydrophilicity in case of being stored in air. So it is critical to find a way to maintain implants’ hydrophilicity. In general, silicate has been known to contribute the hydrophilicity. In this study, the silicate containing CaTiO3 films have been prepared on Ti substrates by two-step treatment for biomaterial applications. The hydrophilicity, osteoconductivity and protein adsorption of treated specimens have been investigated. The 1st step treatment for Ti is to form TiO2 as precursors, either by anodizing in sulfuric acid solution at 298 K, liquid phase oxidation in nitric acid solution with hydrogen peroxide at 353 K, or thermal oxidation at 673 K in air. Hydrothermal treatment in silicate containing alkaline solution is the 2nd step to convert TiO2 to silicate containing CaTiO3 films. The SEM, XRD, XPS, WCA (water contact angle) investigations and protein adsorption measurements have been carried out to characterize the surface properties. This surface maintained 10 deg. in WCA after 7 d exposure in air, while the specimen without silicate has WCA of more than 40 deg. The osteoconductivity is evaluated based on the contact ratio of formed hard tissue on the implanted specimens after 14 d implantation in rats’ tibia at in vivo test. The as-prepared film not only has exhibited smooth and superhydrophilic surface, but also has achieved high osteoconductivity and great protein adsorption capacity.

Fig. 1 Change in water contact angle of Ti with storage time in air (gray circle as-polished Ti) after anodizing in (a) 0.1 M Na2SiO3, (b) 1 M Na2SiO3, and (c) 0.1 M NaOH solutions. Internal profiles are XPS results for (a) and (c). Fullsize Image
© 2019 The Japan Institute of Metals and Materials
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