Article ID: M2012417
Ordered mesoporous SiO2–CaO–P2O5 bioactive glass with a highly specific surface area has been synthesized through a sol–gel process in the presence of a nonionic triblock copolymer acting as a template. The amorphous silicate can be detected on the mesoporous SiO2–CaO–P2O5 bioactive glass. The mesoporous SiO2–CaO–P2O5 bioactive glass exhibits the type IV isotherm curve with average pore size of 5.3 nm and high specific surface area of 317.24 m2/g for calcination at 600°C. Owing to the high specific surface area and pore volume, the mesoporous SiO2–CaO–P2O5 had a significantly enhanced bone-forming bioactivity compared with the conventional bioactive glass. After soaking the mesoporous SiO2–CaO–P2O5 in simulated body fluid (SBF) for 10 h, it can be observed that the formation of apatite nanocrystals occurs on the surface of the bioactive glass. It is anticipated that mesoporous SiO2–CaO–P2O5 with a controlled mesostructure may be potentially useful as novel tissue-engineering scaffolds in bone regeneration.