Osteoporosis is the disease in the condition that the activity of the osteoclast surpasses that of the osteoblast. A variety of endocrine hormones, such as PTH play the important roles in the bone remodeling. Recently, several kinds of evidence including basic science and clinical studies show that the stain has the positive effect on bone formation. Therefore, in this review, we show the studies about the mechanism how the statin works on the osteoblast using the chondrocyte cell line; ATDC5 cells, and mouse tibia organ culture. Furthermore, the series of recent metaanalysis of the statin and osteoporosis are discussed.
