MEMBRANE
Online ISSN : 1884-6440
Print ISSN : 0385-1036
ISSN-L : 0385-1036
Characterization of the Physicochemical Properties of Micelles of the Novel Platelet Activating Factor Receptor Antagonist, E5880
Yasuyuki Asai
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2003 Volume 28 Issue 3 Pages 145-150

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Abstract

E5880, a novel platelet activating factor receptor antagonist, was dispersed in water for use in injectable formulation and the physicochemical properties of the preparation were characterized. The critical concentration for formation of micelles was 0.12 mM. Using area per molecule data, the critical packing parameter was calculated, indicating that the structure of the micelles was spherical and that each micelle containing 49 molecules. The diameter of the micelle was 8.1 nm. The micropolarity in the vicinity of the hydrocarbon region of the micelles was evaluated and compared with other surfactants, including stearyltrimethylammonium chloride and certyltrimethylammonium chroride.

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