Online ISSN : 1884-6440
Print ISSN : 0385-1036
ISSN-L : 0385-1036
上皮膜輸送を介する浸透圧感受機構
新里 直美丸中 良典
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ジャーナル フリー

2004 年 29 巻 3 号 p. 161-168

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To sense an environmental change such as hypotonic shock is a crucial function for cells to adjust to a new environment. Na+ reabsorption in the kidney is finely regulated to maintain body Na+ content, blood pressure, extracellular fluid volume (ECF) and is stimulated by aldosterone, vasopression and extracellular hypotonicity to maintain normal plasma osmolality. On the other hand, hypotonic shock causes drastic cell volume changes; initial cell swelling followed by regulatory volume decrease (RVD). The mechanism of RVD is well understood as K+/Cl-release through volume-sensitive Cl-and K+ channels and a decrease in cytosolic Cl-concentration is associated with the RVD. In this review, we focus our study on a possible role of cytosolic Cl-for sensing extracellular hypotonicity by modulating enzyme activities to regulate tyrosine phosphorylation and suggest the possibility that ion channels and ion transporters function as regulators of signal transduction for extracellular stimuli in addition to the contribution to transepithelial ion transporter.

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