2016 Volume 34 Issue 2 Pages 82-88
The aim of this review is to introduce history, basis and current status of in vivo diagnostic imaging technologies, and discuss future directions of in vivo cancer molecular imaging research and development especially toward practical and useful clinical applications. I focus on two concepts; multiplexed imaging and activatable probes, for improving specificity and sensitivity of the molecular imaging technology. Additionally, I introduce a newly developed super-specific cancer therapy, near infrared photo-immunotherapy, which is evolved from the bio-imaging technology that based on integrated multidisciplinary sciences.