Interpretation of Diffusion MR Imaging Data Using Non-negative Least Squares (NNLS)

Abstract

The interpretation of abdominal diffusion images remains difficult because different types of tissue coexist within each voxel. In this study, we estimated the distribution of the diffusion coefficient (D) within each voxel using non-negative least squares from diffusion-weighted images with multiple b-values. Additionally, a method for visualizing the results as a set of images representing the D ranges was developed. This method was tested on healthy volunteers.