Imaging of Hypoxic Tumor: Correlation between Diffusion-weighted MR Imaging and 18F-fluoroazomycin Arabinoside Positron Emission Tomography in Head and Neck Carcinoma

Akiko Imaizumi; Takayuki Obata; Jeff Kershaw; Yasuhiko Tachibana; Masayuki Inubushi; Mitsuru Koizumi; Kyosan Yoshikawa; Ming-Rong Zhang; Katsuyuki Tanimoto; Rintaro Harada; Takashi Uno; Tsuneo Saga

doi:10.2463/mrms.tn.2019-0007

This article has now been updated. Please use the final version.

Imaging of Hypoxic Tumor: Correlation between Diffusion-weighted MR Imaging and ¹⁸F-fluoroazomycin Arabinoside Positron Emission Tomography in Head and Neck Carcinoma

Akiko Imaizumi, Takayuki Obata, Jeff Kershaw, Yasuhiko Tachibana, Masayuki Inubushi, Mitsuru Koizumi, Kyosan Yoshikawa, Ming-Rong Zhang, Katsuyuki Tanimoto, Rintaro Harada, Takashi Uno, Tsuneo Saga

Author information

Akiko Imaizumi
Applied MRI Research, Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
Takayuki Obata
Applied MRI Research, Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
Jeff Kershaw
Applied MRI Research, Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
Yasuhiko Tachibana
Applied MRI Research, Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
Masayuki Inubushi
Division of Nuclear Medicine, Department of Radiology, Kawasaki Medical School
Mitsuru Koizumi
Department of Nuclear Medicine, Cancer Institute Hospital, Japanese Foundation for Cancer Research
Kyosan Yoshikawa
Advanced Imaging Center, Tokyo Bay Advanced Imaging and Radiation Oncology Clinic Makuhari, Aoikai Medical Corporation
Ming-Rong Zhang
Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
Katsuyuki Tanimoto
Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
Rintaro Harada
Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University
Takashi Uno
Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University
Tsuneo Saga
Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University

Keywords: diffusion-weighted imaging, ¹⁸F-fluoroazomycin arabinoside positron emission tomography, head and neck carcinoma, hypoxia

JOURNAL OPEN ACCESS Advance online publication

Article ID: tn.2019-0007

DOI https://doi.org/10.2463/mrms.tn.2019-0007

The final version of this article is now available: Vol. 19 (2020), No. 3 pp. 276-281

Details

Abstract

We investigated the usefulness of diffusion-weighted imaging (DWI) for detecting changes in the structure of hypoxic cells by evaluating the correlation between ¹⁸F-fluoroazomycin arabinoside (FAZA) positron emission tomography activity and DWI parameters in head and neck carcinoma. The diffusion coefficient corresponding to the slow compartment of a two-compartment model had a significant positive correlation with FAZA activity (ρ = 0.58, P = 0.016), whereas the diffusional kurtosis from diffusion kurtosis imaging had a significant negative correlation (ρ = −0.62, P = 0.008), which suggests that those DWI parameters might be useful as indicators for changes in cell structure.

Corresponding author

Register with J-STAGE for free!