2022 Volume 6 Issue 2 Pages 116-120
Magnetic Particle Imaging (MPI) is an imaging modality that directly detects the nonlinear response of magnetic nanoparticles (MNPs). Spatial encoding is realized by saturating MNPs almost everywhere except in the vicinity of a special point called the field free point (FFP) using a static magnetic field. Recently, it has been shown that the sensitivity of MPI can be significantly improved using a simultaneous encoding scheme by scanning with a field free line (FFL) instead of FFP. The MPI with FFL device was developed using a neodymium magnet and an iron yoke to image the object with small amount of magnetic nanoparticle such as in biological systems. The magnetization response of magnetic nanoparticles in biological systems was studied using the developed MPI device. We developed the imaging system that can evaluate the magnetic signal and relaxation time of magnetic moments which is reflected by core and hydrodynamic size of MNPs. We found that iron concentration changes the MNP size, and then the relaxation time is varied.
