Type B trichothecenes-the relationship between slight structural changes and toxicity

Abstract

  Toxicity evaluation research on type B trichothecene mycotoxins has accumulated various data about their toxicity mechanisms. However, except for end products such as DON or NIV, individual data for derivatives are insufficient because those data were yielded as part of the information about end products. To address this matter, we introduce some speculation about the toxicity characteristics of these trichothecene derivatives using gene expression data derived from DNA microarray analysis. Yeast cell studies suggest that high-sensitivity mycotoxins induce widespread gene expression changes, and that sensitivity has a relationship with plasma membrane transporters. Additionally, these data and previous studies suggest that the toxicity of type B trichothcenes influences mitochondrial ribosomes.