Abstract
ICR mice were fed diets mixed with nivalenol (NIV)-containing moldy rice powder at final levels of NIV of 0, 6, 12 and 30 ppm throughout gestation. Purified NIV was also administered by gavage at doses of 0, 1, 5, 10 and 20mg/kg on days 7-15 of gestation. Four out of five mice in the 20mg/kg group died during the dosing period. The embryotoxicity associated with maternal weight loss was observed in the two groups receiving 30 ppm and 10 mg/kg. Intrauterine growth retardation was found in the term fetuses of mice exposed to 12 ppm and 5 mg/kg. NIV had no statistically significant adverse effects on the incidence of gross, skeletal and visceral malformations.
