1989 Volume 1989 Issue 29 Pages 33-35
In order to investigate whether the dietary NIV modulates the development of carcinogenesis, one week old C57BL/C3H F1 mice were treated with a single i.p. injection of 6 mg/kg of AFB1, and 6 weeks thereafter the diets containing 0, 6 or 12 ppm NIV were fed for 65 weeks. All the male mice i. p. injected with AFB1 developed liver tumor, and that incidence was not altered by feeding of NIV-containing diet. While in the female, the incidence of hepatic tumor in the control, AFB1 alone, AFB1 6 or 12 ppm NIV groups counted for 0, 31, 20 and 0%, respectively. These findings suggested that NIV possesses an ability to depress the incidence of AFB1-initiated hepatocellular carcinogenesis at the promotion stage in female mice.
