CLINICAL EVALUATION OF SEVERAL DEPRESSANT DRUGS FROM VIEWPOINT OF HEMODYNAMIC ANALYSIS

Abstract

The circulatory dynamics were serially examined in the hypertensive cases who were medicated for a long term with several depressant drugs.
1. The blood pressure lowers in the initial stage of the Rauwolfia serpentina application, but the peripheral resistance does not decrease. The depression at this term is due to mainly the reduction of cardiac output. Such a hemodynamic state is not favourable. By means of further medication, the blood pressure tends rather to elevate to some extent, but remains under the control level. The total peripheral resistance significantly decreases, and approaches to normal range. This slight change of initially depressed blood pressure is due to the moderate increase of cardiac output. So-called dynamical mean pressure is kept on lower level.
2. By the chronic use of 1-Hydrazinophthalazine (Apresoline “Ciba”) the cardiac rates increase slightly, but both stroke and minute volume decrease markedly. The agent also reduces elasticity modulus and total peripheral resistance. From theoretical viewpoint such a hemodynamic state is favourable.
3. The circulatory dynamics were examined in the hypertensive cases who were medicated parenterally with ganglionic blocking agents. The decrease of cardiac output and the increase of peripheral resistance are observed during depression; such a hemodynamic condition is not favourable. But these results do not necessarily mean that the ganglionic blocking drugs are not suitable for the therapy of the high blood pressure, because these results were obtained merely by the acute use, so the increase of peripheral resistance is considered to be due to the homeostasis against the abrupt hypotension which is brought by the medication of this sort of agents.