1956 年 44 巻 11 号 p. 1071-1078
I have compounded six Flavonoids and used them clinically; they are Rutin, Rutin-diphosphate, Quercetin, Myricitrin, 3′, 4′ Dihydroxy-Flavonol and 6-Chloro-3′, 4′ Dihydroxy-Flavonol.
Quercetin which is first used clinically showed a very nice effect upon capillary fragility in comparison with popular capillary stabilizer and moreover showed the strong inhibition against Choline Acetylase.
Ascorbic acid showed the strongest inhibition against Choline Acetylase and its joint use with Flavonoids strengthened the effect clinically and also in Choline Acetylase inhibition.
Parotin showed the Choline Acetylase inhibition as well as Cortisone and ACTH.
The fact that the clinical effect of Flavonoids is parallel with its Choline Acetylase inhibition rate suggests that such a mechanism is held also in vivo.