P³²による實驗的日本腦炎に關する研究

第1篇 腦内病毒接種マウス腦及び肝に於ける核酸代謝のSchneider法による研究

抄録

Nucleic acid metabolism in brain and liver of the mouse infected with Japanese Bencephalitis was investigated using the radioactive P³².
The mice intracerebrally inoculated with Japanese B encephalitis virus were intraperitoneally injected with P³² 48 hours and 96 hours after the inoculation of virus.
A certain portion of brain and liver of the mouse was 12 hours after the injection fractionated according to Schneider's method.
The P³² activities in each fraction of the infected group as well as of the not-infected control group were compared with each other.
Marked increase of P³² activities in the phosphoprotein and nucleic acids fractions of brain and liver at the acme stage of infection were clearly seen in the infected group.
In the liver of the infected mouse the increase in P³² activity has already been recogneized in the incubation period, that is, in so-called visceral phase of this disease.