コバルトの貧血に及ぼす實驗的並びに臨床的効果 (第1報)

抄録

As the basis of treatment of anemia by cobalt, experimental anemia in rabbits was used, and compared with the effect of cobalt and that of iron.
Cobalt produced excellent effect than iron on the infectious anemia, associated with sterile inflammation induced by the intramuscular injection of turpentine in the rabbits. Also cobalt produced similar effect on the anemia, due to staphylococcal infection by the intramuscular injection. But there is no effect on the phenylhydrazine anemia and less effect on anemia due to bleeding.
The daily oral dosage of 30-60 mg of cobaltous chloride administered to 35 patients with various types of anemia produced erythropoetic responses in 10 cases.
In 6 of 10 patients with iron deficiency anemia, in 2 of 8 patients with infectious anemia, and 1 patient with inoperable sarcoma of stomach, definite reticulocytic responses and increase in red cells, hemoglobin and hematocrit values were observed.
But in cases with refractory anemia, chronic nephritis, thrombocytopenic purpura, and leukemia no effect were observed.
Effect of cobalt on the iron refractory anemias, especially on infectious anemia and anemia due to tumor was discussed.