1956 Volume 45 Issue 2 Pages 91-101
The present study is concerned with the histopathological findings of the liver and the spleen of rabbits, which were used for the previous investigation of the influence of pituitary and adrenal hormones on the function of RES.
The results are as follows.
1. The weight of the spleen increased in the animals administered with DOCA and ACTH, but decreased in those administered with cortisone.
2. The histological changes of the spleen of the animals treated with DOCA and cortisone showed a clear difference. ACTH induced almost the same changes as those induced by DOCA.
3. The weight of the liver on the contrary to the spleen decreased by DOCA and ACTH and increased by cortisone.
4. The changes of histological findings induced by DOCA and cortisone were also clearly different. DOCA induced the shrinking of liver cells and the expansion of hepatic sinusoids. On the other hand, the swelling and brightening of liver cells and the closing of hepatic sinusoids were seen in the animals treated with cortisone. The administration of ACTH causes the same changes as those by DOCA.
5. There is a close relation between the histological changes of the liver and the sleen and the changes of function of RES to take off the intravenously injected chicken blood cells.
6. The mechanism of the hormonal regulation of RES was discussed on the basis of these histological findings.
